p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).
作者:
主题词
动物(Animals);喜树碱(Camptothecin);羧酸酯酶(Carboxylesterase);羧酸酯水解酶类(Carboxylic Ester Hydrolases);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶抑制剂(Enzyme Inhibitors);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);人类(Humans);肝(Liver);兔(Rabbits);转染(Transfection);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1124/jpet.102.044149
PMID
12538824
发布时间
2018-11-30
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