Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes.
第一作者:
David,Holzberg
第一单位:
Institute of Pharmacology, Medical School Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany.
作者:
医学主题词
氨基酸序列(Amino Acid Sequence);细胞凋亡(Apoptosis);碱基序列(Base Sequence);细胞, 培养的(Cells, Cultured);DNA, 互补(DNA, Complementary);基因表达调控(Gene Expression Regulation);人类(Humans);炎症(Inflammation);白细胞介素1(Interleukin-1);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);大分子物质(Macromolecular Substances);丝裂原激活蛋白激酶类(Mitogen-Activated Protein Kinases);分子序列数据(Molecular Sequence Data);肽碎片(Peptide Fragments);磷酰化(Phosphorylation);蛋白质结构, 三级(Protein Structure, Tertiary);原癌基因蛋白质c-jun(Proto-Oncogene Proteins c-jun);重组蛋白质类(Recombinant Proteins);信号传导(Signal Transduction);转录因子AP-1(Transcription Factor AP-1)
DOI
10.1074/jbc.M304058200
PMID
12832416
发布时间
2021-02-09
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