换一批Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.
第一作者：
Jörg J,Jacoby
第一单位：
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
作者：
医学主题词
衰老(Aging);等位基因(Alleles);动物(Animals);DNA结合蛋白质类(DNA-Binding Proteins);多柔比星(Doxorubicin);超声心动描记术(Echocardiography);纤维化(Fibrosis);心力衰竭(Heart Failure);炎症(Inflammation);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌细胞(Muscle Cells);心肌(Myocardium);STAT3转录因子(STAT3 Transcription Factor);反式激活因子类(Trans-Activators);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);心室功能, 左(Ventricular Function, Left)
DOI
10.1073/pnas.2134694100
PMID
14566054
发布时间
2022-03-09
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