换一批Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice.
第一作者：
Jun-Sheng,Wang
第一单位：
Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA.
作者：
医学主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);动物(Animals);曲线下面积(Area Under Curve);生物利用度(Biological Availability);生物转运(Biological Transport);血脑屏障(Blood-Brain Barrier);色谱法, 高压液相(Chromatography, High Pressure Liquid);男(雄)性(Male);美沙酮(Methadone);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);麻醉品(Narcotics);吡咯烷类(Pyrrolidines);组织分布(Tissue Distribution)
DOI
10.1007/s00213-003-1718-1
PMID
14712343
发布时间
2018-11-30
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Psychopharmacology
132-8页
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