Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells.
第一作者:
Yolanda,Romsicki
第一单位:
Department of Biochemistry & Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe-Claire-Dorval, Quebec H9R 4P8, Canada.
作者:
医学主题词
印迹法, 蛋白质(Blotting, Western);细胞系(Cell Line);细胞膜(Cell Membrane);DNA, 互补(DNA, Complementary);剂量效应关系, 药物(Dose-Response Relationship, Drug);内质网(Endoplasmic Reticulum);内颗粒(Endosomes);酶抑制剂(Enzyme Inhibitors);荧光共振能量转移(Fluorescence Resonance Energy Transfer);遗传载体(Genetic Vectors);绿色荧光蛋白质类(Green Fluorescent Proteins);人类(Humans);图像处理, 计算机辅助(Image Processing, Computer-Assisted);胰岛素(Insulin);动力学(Kinetics);发光蛋白质类(Luminescent Proteins);显微镜检查, 共焦(Microscopy, Confocal);显微镜检查, 荧光(Microscopy, Fluorescence);模型, 化学(Models, Chemical);磷酰化(Phosphorylation);沉淀素试验(Precipitin Tests);蛋白质结合(Protein Binding);蛋白质结构, 三级(Protein Structure, Tertiary);蛋白质酪氨酸磷酸酶, 非受体1型(Protein Tyrosine Phosphatase, Non-Receptor Type 1);蛋白质酪氨酸磷酸酶类(Protein Tyrosine Phosphatases);受体, 胰岛素(Receptor, Insulin);重组融合蛋白质类(Recombinant Fusion Proteins);信号传导(Signal Transduction);转染(Transfection)
DOI
10.1074/jbc.M309600200
PMID
14722096
发布时间
2021-02-06
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