Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.
第一作者:
Iris T,Chan
第一单位:
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
作者:
主题词
腺瘤(Adenoma);等位基因(Alleles);动物(Animals);骨髓细胞(Bone Marrow Cells);骨髓移植(Bone Marrow Transplantation);细胞, 培养的(Cells, Cultured);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因, ras(Genes, ras);造血干细胞(Hematopoietic Stem Cells);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);小鼠(Mice);小鼠, 近交系(Mice, Inbred Strains);小鼠, 转基因(Mice, Transgenic);骨髓增殖性疾病(Myeloproliferative Disorders);肿瘤(Neoplasms);乳头状瘤(Papilloma);表型(Phenotype);启动区, 遗传(Promoter Regions, Genetic)
DOI
10.1172/JCI20476
PMID
14966562
发布时间
2024-11-22
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