换一批Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.
第一作者：
Amedeo,Leonardi
第一单位：
Pharmaceutical R & D Division, Recordati s.p.a., Via Civitali 1, 20148 Milan, Italy. Leonardi.A@recordati.it
作者：
医学主题词
肾上腺素能α-1受体拮抗剂(Adrenergic alpha-1 Receptor Antagonists);肾上腺素能α拮抗剂(Adrenergic alpha-Antagonists);氨基酸序列(Amino Acid Sequence);动物(Animals);结合部位(Binding Sites);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);豚鼠(Guinea Pigs);人类(Humans);酰亚胺类(Imides);配体(Ligands);男(雄)性(Male);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);肌收缩(Muscle Contraction);肌, 平滑, 血管(Muscle, Smooth, Vascular);蛋白质结构, 三级(Protein Structure, Tertiary);放射配体测定(Radioligand Assay);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 血清素, 5-HT1A(Receptor, Serotonin, 5-HT1A);受体, 肾上腺素能α1(Receptors, Adrenergic, alpha-1);序列比对(Sequence Alignment);血清素5-HT1受体拮抗剂(Serotonin 5-HT1 Receptor Antagonists);螺环化合物(Spiro Compounds);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm030944+
PMID
15055991
发布时间
2025-05-29
- 浏览11
Journal of medicinal chemistry
1900-18页
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