Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.
作者:
主题词
基膜(Basement Membrane);细胞系, 肿瘤(Cell Line, Tumor);趋化因子CXCL12(Chemokine CXCL12);趋化因子, CXC(Chemokines, CXC);酶激活(Enzyme Activation);人类(Humans);淋巴转移(Lymphatic Metastasis);基质金属蛋白酶类, 膜相关(Matrix Metalloproteinases, Membrane-Associated);黑色素瘤(Melanoma);金属内肽酶类(Metalloendopeptidases);肿瘤侵润(Neoplasm Invasiveness);受体, CXCR4(Receptors, CXCR4);转染(Transfection);转化生长因子β(Transforming Growth Factor beta);转化生长因子β1(Transforming Growth Factor beta1);增量调节(Up-Regulation);cdc42 GTP结合蛋白质(cdc42 GTP-Binding Protein);rac1 GTP结合蛋白质(rac1 GTP-Binding Protein);ρGTP结合蛋白质类(rho GTP-Binding Proteins);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)
DOI
10.1158/0008-5472.can-03-3398
PMID
15059909
发布时间
2019-11-08
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Cancer research
2534-43页
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