Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
第一作者:
Marco,Sandri
第一单位:
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
作者:
医学主题词
腺病毒科(Adenoviridae);动物(Animals);细胞, 培养的(Cells, Cultured);克隆, 分子(Cloning, Molecular);禁食(Fasting);基因表达调控(Gene Expression Regulation);遗传载体(Genetic Vectors);糖皮质激素类(Glucocorticoids);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);连接酶类(Ligases);小鼠(Mice);模型, 生物学(Models, Biological);肌细胞(Muscle Cells);肌蛋白质类(Muscle Proteins);肌, 骨骼(Muscle, Skeletal);肌萎缩(Muscular Atrophy);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);RNA干扰(RNA Interference);SKP Cullin F-框蛋白质连接酶类(SKP Cullin F-Box Protein Ligases);信号传导(Signal Transduction);转录因子(Transcription Factors);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1016/s0092-8674(04)00400-3
PMID
15109499
发布时间
2022-04-08
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Cell
399-412页
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