Inhibitory effects of tetrandrine on the serum- and platelet-derived growth factor-BB-induced proliferation of rat aortic smooth muscle cells through inhibition of cell cycle progression, DNA synthesis, ERK1/2 activation and c-fos expression.
作者:
主题词
生物碱类(Alkaloids);方差分析(Analysis of Variance);动物(Animals);主动脉(Aorta);苄异喹啉类(Benzylisoquinolines);印迹法, 蛋白质(Blotting, Western);细胞周期(Cell Cycle);细胞分裂(Cell Division);细胞, 培养的(Cells, Cultured);DNA(DNA);酶激活(Enzyme Activation);男(雄)性(Male);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);丝裂原激活蛋白激酶类(Mitogen-Activated Protein Kinases);肌, 平滑, 血管(Muscle, Smooth, Vascular);肌细胞, 平滑肌(Myocytes, Smooth Muscle);血小板源性生长因子(Platelet-Derived Growth Factor);聚合酶链反应(Polymerase Chain Reaction);概率(Probability);原癌基因蛋白质c-fos(Proto-Oncogene Proteins c-fos);原癌基因蛋白质c-sis(Proto-Oncogene Proteins c-sis);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);敏感性与特异性(Sensitivity and Specificity)
DOI
10.1016/j.atherosclerosis.2004.01.036
PMID
15136051
发布时间
2018-11-30
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Atherosclerosis
215-23页
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