Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.

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作者： Nebojsa,Mirkovic ^[1] ; Marc A,Marti-Renom ; Barbara L,Weber ; Andrej,Sali ; Alvaro N A,Monteiro

作者单位： Laboratory of Molecular Biophysics, Pels Family Center for Biochemistry and Structural Biology, Rockefeller University, New York, New York, USA. ^[1]

主题词 BRCA1蛋白质(BRCA1 Protein);乳腺肿瘤(Breast Neoplasms);女(雌)性(Female);基因, BRCA1(Genes, BRCA1);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);突变, 误义(Mutation, Missense);卵巢肿瘤(Ovarian Neoplasms);系谱(Pedigree);蛋白质构象(Protein Conformation);构效关系(Structure-Activity Relationship);转录激活(Transcriptional Activation)

DOI 10.1158/0008-5472.CAN-03-3009

PMID 15172985

发布时间 2008-11-21

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Cancer research

2004年64卷11期

3790-7页

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Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.

Cancer research

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Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.

Cancer research

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Cancer research

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