Prediction of the affinity of the newly synthesised azapirone derivatives for 5-HT1A receptors based on artificial neural network analysis of chromatographic retention data and calculation chemistry parameters.
第一作者:
Antoni,Nasal
第一单位:
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gen. J. Hallera 107, PL-80-416 Gdansk, Poland. antonasa@amg.gda.pl
作者:
医学主题词
氮杂化合物(Aza Compounds);丁螺环酮(Buspirone);化学现象(Chemical Phenomena);化学, 物理(Chemistry, Physical);色谱法(Chromatography);色谱法, 高压液相(Chromatography, High Pressure Liquid);试验预期值(Predictive Value of Tests);量化构效关系(Quantitative Structure-Activity Relationship);受体, 血清素, 5-HT1A(Receptor, Serotonin, 5-HT1A);血清素类药(Serotonin Agents);血清素受体激动剂(Serotonin Receptor Agonists);螺环化合物(Spiro Compounds)
DOI
10.2174/1386207043328742
PMID
15200379
发布时间
2019-12-10
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