Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction.
作者:
主题词
CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞核(Cell Nucleus);DNA结合蛋白质类(DNA-Binding Proteins);基因产物, nef(Gene Products, nef);基因产物, tat(Gene Products, tat);HIV感染(HIV Infections);HIV-1(HIV-1);人类(Humans);白细胞介素2(Interleukin-2);Jurkat细胞(Jurkat Cells);NF-κB(NF-kappa B);NFATC转录因子类(NFATC Transcription Factors);核蛋白质类(Nuclear Proteins);启动区, 遗传(Promoter Regions, Genetic);转录因子AP-1(Transcription Factor AP-1);转录因子(Transcription Factors);nef基因产物, 人免疫缺陷病毒(nef Gene Products, Human Immunodeficiency Virus);tat基因产物, 人免疫缺陷病毒(tat Gene Products, Human Immunodeficiency Virus)
DOI
10.1074/jbc.M407477200
PMID
15258149
发布时间
2021-02-09
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