换一批Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.
第一作者：
Purva,Bali
第一单位：
Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute University of South Florida, Tampa, Florida 33612, USA.
作者：
医学主题词
抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);DNA(DNA);DNA结合蛋白质类(DNA-Binding Proteins);剂量效应关系, 药物(Dose-Response Relationship, Drug);减量调节(Down-Regulation);药物协同作用(Drug Synergism);酶抑制剂(Enzyme Inhibitors);外显子(Exons);流式细胞术(Flow Cytometry);G1期(G1 Phase);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);羟肟酸类(Hydroxamic Acids);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);乳蛋白质类(Milk Proteins);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);突变(Mutation);磷酰化(Phosphorylation);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);蛋白质结合(Protein Binding);蛋白质结构, 三级(Protein Structure, Tertiary);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);RNA, 信使(RNA, Messenger);受体蛋白质酪氨酸激酶类(Receptor Protein-Tyrosine Kinases);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);STAT5转录因子(STAT5 Transcription Factor);信号传导(Signal Transduction);星状孢子素(Staurosporine);时间因素(Time Factors);反式激活因子类(Trans-Activators);fms样酪氨酸激酶3(fms-Like Tyrosine Kinase 3)
DOI
10.1158/1078-0432.CCR-04-0210
PMID
15297399
发布时间
2021-12-03
- 浏览23
Clinical cancer research
4991-7页
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