换一批
换一批Anti-apoptotic action of (2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378) by suppression of the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and increased phosphorylation of casein kinase2/Akt/ cyclic AMP response element binding protein via maxi-K channel opening in neuronal cells.
第一作者：
Ki Young,Kim
第一单位：
Medicinal Science Division, Korea Research Institute of Chemical Technology, Yuseong, Daejeon 305-600, Korea.
作者：
主题词
细胞凋亡(Apoptosis);酪蛋白激酶Ⅱ(Casein Kinase II);细胞存活(Cell Survival);环AMP(Cyclic AMP);cAMP反应元件结合蛋白质(Cyclic AMP Response Element-Binding Protein);胍类(Guanidines);人类(Humans);离子通道闸门(Ion Channel Gating);大电导钙激活钾通道(Large-Conductance Calcium-Activated Potassium Channels);膜电位(Membrane Potentials);线粒体(Mitochondria);神经元(Neurons);PTEN磷酸水解酶(PTEN Phosphohydrolase);膜片钳术(Patch-Clamp Techniques);肽类(Peptides);磷酸单酯水解酶类(Phosphoric Monoester Hydrolases);磷酰化(Phosphorylation);钾通道阻滞剂(Potassium Channel Blockers);钾通道, 钙激活(Potassium Channels, Calcium-Activated);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);吡喃类(Pyrans);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);转录因子(Transcription Factors);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1016/j.ejphar.2004.06.058
PMID
15336944
发布时间
2021-12-03
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