Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain.
第一作者:
Helen,Garside
第一单位:
Centre for Molecular Medicine and Endocrine Sciences Research Group, Stopford Building, Faculty of Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.
作者:
医学主题词
别构调节(Allosteric Regulation);DNA(DNA);地塞米松(Dexamethasone);糖皮质激素类(Glucocorticoids);激素拮抗药(Hormone Antagonists);人类(Humans);白细胞介素8(Interleukin-8);配体(Ligands);米非司酮(Mifepristone);NF-κB(NF-kappa B);启动区, 遗传(Promoter Regions, Genetic);蛋白质结构, 三级(Protein Structure, Tertiary);受体, 糖皮质激素(Receptors, Glucocorticoid);转录因子RelA(Transcription Factor RelA)
DOI
10.1074/jbc.M407309200
PMID
15355994
发布时间
2021-02-09
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