换一批
换一批A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
作者：
主题词
成年人(Adult);选择性剪接(Alternative Splicing);氨基酸序列(Amino Acid Sequence);动物(Animals);脑化学(Brain Chemistry);细胞系, 肿瘤(Cell Line, Tumor);剂量效应关系, 药物(Dose-Response Relationship, Drug);探究行为(Exploratory Behavior);女(雌)性(Female);手部肌力(Hand Strength);人类(Humans);核内包涵体(Intranuclear Inclusion Bodies);Machado-Joseph病(Machado-Joseph Disease);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);小卫星重复(Minisatellite Repeats);分子序列数据(Molecular Sequence Data);神经组织蛋白质类(Nerve Tissue Proteins);神经母细胞瘤(Neuroblastoma);神经元(Neurons);核蛋白质类(Nuclear Proteins);肽碎片(Peptide Fragments);表型(Phenotype);姿势平衡(Postural Balance);反射(Reflex);阻遏蛋白质类(Repressor Proteins);亚细胞部分(Subcellular Fractions);黑质(Substantia Nigra);转录因子(Transcription Factors);转染(Transfection)
DOI
10.1523/JNEUROSCI.2734-04.2004
PMID
15537899
发布时间
2020-02-25
- 浏览15
The Journal of neuroscience
10266-79页
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