LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.
作者:
主题词
动物(Animals);碱基序列(Base Sequence);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);载体蛋白质类(Carrier Proteins);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);染色体, 人, 3对(Chromosomes, Human, Pair 3);DNA(DNA);DNA结合蛋白质类(DNA-Binding Proteins);E2F转录因子类(E2F Transcription Factors);E2F1转录因子(E2F1 Transcription Factor);纤维肉瘤(Fibrosarcoma);基因, 肿瘤抑制(Genes, Tumor Suppressor);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 裸(Mice, Nude);肿瘤移植(Neoplasm Transplantation);蛋白质结合(Protein Binding);阻遏蛋白质类(Repressor Proteins);视网膜母细胞瘤蛋白质(Retinoblastoma Protein);亚细胞部分(Subcellular Fractions);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic);移植, 异种(Transplantation, Heterologous);肿瘤干细胞测定(Tumor Stem Cell Assay);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1073/pnas.0407123101
PMID
15542589
发布时间
2024-11-22
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