换一批
换一批RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.
第一作者：
Ivan,Plaza Menacho
第一单位：
Department of Medical Genetics, University of Groningen, Groningen, the Netherlands.
作者：
主题词
腺苷三磷酸(Adenosine Triphosphate);氨基酸取代(Amino Acid Substitution);动物(Animals);印迹法, 蛋白质(Blotting, Western);癌, 髓样(Carcinoma, Medullary);细胞膜(Cell Membrane);细胞核(Cell Nucleus);细胞, 培养的(Cells, Cultured);DNA结合蛋白质类(DNA-Binding Proteins);酶激活(Enzyme Activation);胶质细胞源性神经营养因子(Glial Cell Line-Derived Neurotrophic Factor);人类(Humans);免疫酶技术(Immunoenzyme Techniques);免疫沉淀法(Immunoprecipitation);Janus激酶1(Janus Kinase 1);Janus激酶2(Janus Kinase 2);萤光素酶类(Luciferases);多发性内分泌瘤病2a型(Multiple Endocrine Neoplasia Type 2a);突变(Mutation);神经生长因子类(Nerve Growth Factors);癌基因蛋白质类(Oncogene Proteins);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-ret(Proto-Oncogene Proteins c-ret);原癌基因蛋白质类pp60(c-src)(Proto-Oncogene Proteins pp60(c-src));受体蛋白质酪氨酸激酶类(Receptor Protein-Tyrosine Kinases);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);甲状腺肿瘤(Thyroid Neoplasms);反式激活因子类(Trans-Activators)
DOI
10.1158/0008-5472.CAN-04-2363
PMID
15753368
发布时间
2021-12-03
- 浏览14
Cancer research
1729-37页
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