换一批Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
第一作者：
Devin M,Swanson
第一单位：
Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA.
作者：
医学主题词
投药, 口服(Administration, Oral);氨基吡啶类(Aminopyridines);镇痛药(Analgesics);动物(Animals);生物利用度(Biological Availability);体温(Body Temperature);钙(Calcium);辣椒辣素(Capsaicin);细胞系(Cell Line);人类(Humans);低温(Hypothermia);离子通道(Ion Channels);男(雄)性(Male);疼痛测定(Pain Measurement);哌嗪类(Piperazines);大鼠(Rats);构效关系(Structure-Activity Relationship);TRPV阳离子通道(TRPV Cation Channels)
DOI
10.1021/jm0495071
PMID
15771431
发布时间
2013-11-21
- 浏览45
Journal of medicinal chemistry
1857-72页
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