Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.
第一作者:
Yankun,Li
第一单位:
Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
作者:
主题词
动物(Animals);动脉硬化(Arteriosclerosis);生物转运(Biological Transport);细胞核(Cell Nucleus);胆固醇(Cholesterol);细胞因子类(Cytokines);胞质溶胶(Cytosol);内质网(Endoplasmic Reticulum);酶激活(Enzyme Activation);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);女(雌)性(Female);免疫印迹法(Immunoblotting);炎症(Inflammation);白细胞介素6(Interleukin-6);MAP激酶信号系统(MAP Kinase Signaling System);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);模型, 生物学(Models, Biological);NF-κB(NF-kappa B);蛋白质折叠(Protein Folding);RNA, 信使(RNA, Messenger);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);时间因素(Time Factors);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1074/jbc.M501759200
PMID
15826936
发布时间
2022-03-17
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