换一批
换一批Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines.
作者：
主题词
乙酰基转移酶类(Acetyltransferases);抗肿瘤药(Antineoplastic Agents);印迹法, 蛋白质(Blotting, Western);细胞系, 肿瘤(Cell Line, Tumor);染色质(Chromatin);DNA, 互补(DNA, Complementary);缩肽类(Depsipeptides);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);组蛋白酰基转移酶(Histone Acetyltransferases);组蛋白脱乙酰基酶类(Histone Deacetylases);人类(Humans);免疫沉淀法(Immunoprecipitation);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);启动区, 遗传(Promoter Regions, Genetic);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);增量调节(Up-Regulation)
DOI
10.1124/jpet.105.083956
PMID
15833893
发布时间
2018-12-01
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