Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.-论文-万方医学网

作者： Gabor C,Petzold ^[1] ; Olaf,Windmüller ; Stephan,Haack ; Sebastian,Major ; Katharina,Buchheim ; Dirk,Megow ; Siegrun,Gabriel ; Thomas-Nicolas,Lehmann ; Christoph,Drenckhahn ; Oliver,Peters ; Hartmut,Meierkord ; Uwe,Heinemann ; Ulrich,Dirnagl ; Jens P,Dreier

作者单位： Department of Neurology, Charité-University Medicine Berlin, Berlin, Germany. ^[1]

主题词 2-氨基-5-膦酰基戊酸盐(2-Amino-5-phosphonovalerate);动物(Animals);体温(Body Temperature);脑(Brain);脑损伤(Brain Injuries);皮质传播抑制(Cortical Spreading Depression);地卓西平马来酸盐(Dizocilpine Maleate);电极(Electrodes);兴奋性氨基酸拮抗剂(Excitatory Amino Acid Antagonists);人类(Humans);离子(Ions);缺血(Ischemia);激光多普勒流量测定(Laser-Doppler Flowmetry);男(雄)性(Male);神经保护药(Neuroprotective Agents);钾(Potassium);大鼠(Rats);大鼠, Wistar(Rats, Wistar);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);蛛网膜下腔出血(Subarachnoid Hemorrhage)

DOI 10.1161/01.STR.0000166023.51307.e0

PMID 15879337

发布时间 2016-11-22

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Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.

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Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.

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