Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells.
第一作者:
Timo,Siitonen
第一单位:
Department of Internal Medicine, University of Oulu, PL 20, OYS 90029, Finland. timo.siitonen@ppshp.fi
作者:
医学主题词
丁酸盐类(Butyrates);细胞周期(Cell Cycle);细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);细胞周期蛋白D1(Cyclin D1);周期素依赖激酶抑制剂p27(Cyclin-Dependent Kinase Inhibitor p27);阿糖胞苷(Cytarabine);酶抑制剂(Enzyme Inhibitors);依托泊甙(Etoposide);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);丙戊酸(Valproic Acid)
DOI
10.1016/j.leukres.2005.04.018
PMID
15936818
发布时间
2013-11-21
- 浏览13
Leukemia research
1335-42页
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