换一批
换一批The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine.
作者：
主题词
动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞系, 肿瘤(Cell Line, Tumor);达卡巴嗪(Dacarbazine);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);鸟嘌呤(Guanine);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);突变(Mutation);O(6)-甲基鸟嘌呤DNA甲基转移酶(O(6)-Methylguanine-DNA Methyltransferase);转导, 遗传(Transduction, Genetic);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1002/jgm.816
PMID
16075413
发布时间
2018-12-03
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