Selenium disrupts estrogen receptor (alpha) signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells.
第一作者:
Yatrik M,Shah
第一单位:
Department of Structural and Cellular Biology, SL49, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
作者:
主题词
乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);子宫内膜肿瘤(Endometrial Neoplasms);雌激素拮抗剂(Estrogen Antagonists);雌激素受体α(Estrogen Receptor alpha);雌激素受体β(Estrogen Receptor beta);女(雌)性(Female);基因表达(Gene Expression);人类(Humans);肿瘤, 激素依赖性(Neoplasms, Hormone-Dependent);有机硒化合物(Organoselenium Compounds);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);RNA, 信使(RNA, Messenger);信号传导(Signal Transduction);他莫昔芬(Tamoxifen);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1158/1535-7163.MCT-05-0046
PMID
16093440
发布时间
2020-09-30
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Molecular cancer therapeutics
1239-49页
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