Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes.
第一作者:
Sergei,Vatolin
第一单位:
Laboratory of Immunopathology, National Institutes of Allergy and Infectious Disease, NIH, Bethesda, Maryland, USA.
作者:
主题词
动物(Animals);抗原, 肿瘤(Antigens, Neoplasm);阿扎胞苷(Azacitidine);碱基序列(Base Sequence);细胞系, 肿瘤(Cell Line, Tumor);DNA甲基化(DNA Methylation);DNA结合蛋白质类(DNA-Binding Proteins);成纤维细胞(Fibroblasts);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);遗传载体(Genetic Vectors);人类(Humans);免疫组织化学(Immunohistochemistry);黑素瘤特异性抗原(Melanoma-Specific Antigens);分子序列数据(Molecular Sequence Data);肿瘤蛋白质类(Neoplasm Proteins);核酸构象(Nucleic Acid Conformation);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);RNA, 小分子干扰(RNA, Small Interfering);逆转录病毒科(Retroviridae);转录激活(Transcriptional Activation);转染(Transfection)
DOI
10.1158/0008-5472.CAN-05-0858
PMID
16140943
发布时间
2018-12-01
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Cancer research
7751-62页
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