Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process.
第一作者:
Keiko,Sawabe
第一单位:
Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan. k-sawabe@st.ntu.ac.jp
作者:
医学主题词
动物(Animals);Caco-2细胞(Caco-2 Cells);细胞, 培养的(Cells, Cultured);叶酸拮抗剂(Folic Acid Antagonists);肝细胞(Hepatocytes);人类(Humans);肠黏膜(Intestinal Mucosa);甲氨蝶呤(Methotrexate);苯丙酮尿症(Phenylketonurias);蝶呤类(Pterins);大鼠(Rats)
DOI
10.1016/j.ymgme.2005.06.020
PMID
16165391
发布时间
2023-12-13
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