Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.

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作者： K,Tomita ^[1] ; G,Tamiya ; S,Ando ; K,Ohsumi ; T,Chiyo ; A,Mizutani ; N,Kitamura ; K,Toda ; T,Kaneko ; Y,Horie ; J-Y,Han ; S,Kato ; M,Shimoda ; Y,Oike ; M,Tomizawa ; S,Makino ; T,Ohkura ; H,Saito ; N,Kumagai ; H,Nagata ; H,Ishii ; T,Hibi

作者单位： Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. ^[1]

主题词动物(Animals);细胞凋亡(Apoptosis);细胞黏附分子(Cell Adhesion Molecules);胆碱缺乏症(Choline Deficiency);脂肪肝(Fatty Liver);基因表达调控(Gene Expression Regulation);枯否细胞(Kupffer Cells);肝硬化, 实验性(Liver Cirrhosis, Experimental);男(雄)性(Male);甲硫氨酸(Methionine);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);线粒体, 肝(Mitochondria, Liver);突变(Mutation);RNA, 信使(RNA, Messenger);受体, 肿瘤坏死因子, Ⅰ型(Receptors, Tumor Necrosis Factor, Type I);受体, 肿瘤坏死因子, Ⅱ型(Receptors, Tumor Necrosis Factor, Type II);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);金属蛋白酶1组织抑制剂(Tissue Inhibitor of Metalloproteinase-1);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1136/gut.2005.071118

PMID 16174657

发布时间 2022-04-10

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Gut

2006年55卷3期

415-24页

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Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.

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Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.

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