Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
第一作者:
Stephan E,Lehnart
第一单位:
Clyde and Helen Wu Center for Molecular Cardiology, Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
作者:
主题词
3',5'-环AMP磷酸二酯酶类(3',5'-Cyclic-AMP Phosphodiesterases);动物(Animals);心律失常, 心性(Arrhythmias, Cardiac);环AMP依赖性蛋白激酶类(Cyclic AMP-Dependent Protein Kinases);环核苷酸磷酸二酯酶类, 3型(Cyclic Nucleotide Phosphodiesterases, Type 3);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);心力衰竭(Heart Failure);大分子物质(Macromolecular Substances);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);肌收缩(Muscle Contraction);心肌(Myocardium);肌细胞, 心脏(Myocytes, Cardiac);磷酰化(Phosphorylation);兰尼碱受体钙释放通道(Ryanodine Receptor Calcium Release Channel)
DOI
10.1016/j.cell.2005.07.030
PMID
16213210
发布时间
2018-11-13
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Cell
25-35页
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