Downregulation of the HERG (KCNH2) K(+) channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation.
第一作者:
Hugh,Chapman
第一单位:
Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Haartmaninkatu 8, FI-00290, Helsinki, Finland.
作者:
医学主题词
细胞, 培养的(Cells, Cultured);神经酰胺类(Ceramides);减量调节(Down-Regulation);快速延迟整流钾通道(Ether-A-Go-Go Potassium Channels);基因表达(Gene Expression);人类(Humans);离子通道闸门(Ion Channel Gating);溶酶体(Lysosomes);膜电位(Membrane Potentials);钾通道, 电压门控(Potassium Channels, Voltage-Gated);蛋白质加工, 转译后(Protein Processing, Post-Translational);时间因素(Time Factors);泛素(Ubiquitin)
DOI
10.1242/jcs.02635
PMID
16263765
发布时间
2016-11-24
- 浏览12
Journal of cell science
5325-34页
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