Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.
第一作者:
Wei-Ching,Liang
第一单位:
Department of Protein Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
作者:
主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);细胞系, 肿瘤(Cell Line, Tumor);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);剂量效应关系, 药物(Dose-Response Relationship, Drug);内皮, 血管(Endothelium, Vascular);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);人类(Humans);免疫球蛋白G(Immunoglobulin G);动力学(Kinetics);小鼠(Mice);小鼠, 裸(Mice, Nude);分子序列数据(Molecular Sequence Data);肌, 骨骼(Muscle, Skeletal);肿瘤移植(Neoplasm Transplantation);新生血管化, 病理性(Neovascularization, Pathologic);肽库(Peptide Library);蛋白质结合(Protein Binding);种特异性(Species Specificity);脐静脉(Umbilical Veins);血管内皮生长因子A(Vascular Endothelial Growth Factor A)
DOI
10.1074/jbc.M508199200
PMID
16278208
发布时间
2022-03-11
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