Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.

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作者： Bertrand,Le Bourdonnec ^[1] ; Allan J,Goodman ; Mathieu,Michaut ; Hai-Fen,Ye ; Thomas M,Graczyk ; Serge,Belanger ; Robert N,DeHaven ; Roland E,Dolle

作者单位： Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA. blebourdonnec@adolor.com ^[1]

主题词结晶学, X线(Crystallography, X-Ray);模型, 分子(Models, Molecular);分子构象(Molecular Conformation);哌啶类(Piperidines);受体, 阿片样, μ(Receptors, Opioid, mu);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2005.11.010

PMID 16298525

发布时间 2006-01-09

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Bioorganic & medicinal chemistry letters

2006年16卷4期

864-8页

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Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

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Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

相关期刊

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