Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt.
作者:
主题词
动物(Animals);抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);细胞系(Cell Line);减量调节(Down-Regulation);女(雌)性(Female);自由基清除剂(Free Radical Scavengers);基因表达调控(Gene Expression Regulation);人类(Humans);羟自由基(Hydroxyl Radical);肺(Lung);肺疾病(Lung Diseases);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);粒子大小(Particle Size);磷酰化(Phosphorylation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);RNA, 信使(RNA, Messenger);活性氧(Reactive Oxygen Species);重组蛋白质类(Recombinant Proteins);信号传导(Signal Transduction);硫氧还蛋白质类(Thioredoxins);车辆排放物(Vehicle Emissions)
DOI
10.1016/j.freeradbiomed.2005.07.016
PMID
16298680
发布时间
2009-11-19
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