换一批
换一批Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.
作者：
主题词
结合部位(Binding Sites);印迹法, 蛋白质(Blotting, Western);载体蛋白质类(Carrier Proteins);细胞系, 肿瘤(Cell Line, Tumor);DNA, 互补(DNA, Complementary);剂量效应关系, 药物(Dose-Response Relationship, Drug);抗药性(Drug Resistance);酶抑制剂(Enzyme Inhibitors);遗传载体(Genetic Vectors);基因型(Genotype);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);动力学(Kinetics);模型, 化学(Models, Chemical);模型, 分子(Models, Molecular);突变(Mutation);寡肽类(Oligopeptides);多聚蛋白质类(Polyproteins);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);蛋白质结构, 三级(Protein Structure, Tertiary);RNA(RNA);RNA, 病毒(RNA, Viral);重组蛋白质类(Recombinant Proteins);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);构效关系(Structure-Activity Relationship);时间因素(Time Factors);转染(Transfection);病毒非结构蛋白质类(Viral Nonstructural Proteins);病毒蛋白质类(Viral Proteins)
DOI
10.1074/jbc.M510246200
PMID
16352601
发布时间
2021-02-09
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