Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.
第一作者:
Ismael,Samudio
第一单位:
Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M.D. Anderson Cancer Center, Unit 448, 1400 Holcombe Boulevard, Houston, TX 77030, USA.
作者:
医学主题词
急性病(Acute Disease);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);心磷脂质类(Cardiolipins);细胞分化(Cell Differentiation);细胞外信号调节MAP激酶类(Extracellular Signal-Regulated MAP Kinases);流式细胞术(Flow Cytometry);谷胱甘肽(Glutathione);HL-60细胞(HL-60 Cells);血红素氧化酶(脱环)(Heme Oxygenase (Decyclizing));人类(Humans);异构现象(Isomerism);白血病, 髓样(Leukemia, Myeloid);磷酰化(Phosphorylation);孕二烯类(Pregnadienes);孕烯二酮类(Pregnenediones);孕酮(Progesterone);活性氧(Reactive Oxygen Species);U937细胞(U937 Cells)
DOI
10.1158/1535-7163.MCT-05-0247
PMID
16373713
发布时间
2020-09-30
- 浏览6
Molecular cancer therapeutics
1982-92页
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