Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.

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作者： Christian,Tovar ^[1] ; James,Rosinski ; Zoran,Filipovic ; Brian,Higgins ; Kenneth,Kolinsky ; Holly,Hilton ; Xiaolan,Zhao ; Binh T,Vu ; Weiguo,Qing ; Kathryn,Packman ; Ola,Myklebost ; David C,Heimbrook ; Lyubomir T,Vassilev

作者单位： Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. ^[1]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞周期(Cell Cycle);细胞系(Cell Line);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);咪唑类(Imidazoles);小鼠(Mice);小鼠, 裸(Mice, Nude);肿瘤(Neoplasms);哌嗪类(Piperazines);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);信号传导(Signal Transduction);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1073/pnas.0507493103

PMID 16443686

发布时间 2018-11-13

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Proceedings of the National Academy of Sciences of the United States of America

2006年103卷6期

1888-93页

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.

Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.

Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

相关期刊

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