换一批
换一批Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.
第一作者：
Alain R,Simard
第一单位：
Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier boul., Québec G1V 4G2, Canada.
作者：
主题词
年龄因素(Age Factors);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);动物(Animals);骨髓细胞(Bone Marrow Cells);骨髓移植(Bone Marrow Transplantation);钙结合蛋白质类(Calcium-Binding Proteins);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);基因表达(Gene Expression);绿色荧光蛋白质类(Green Fluorescent Proteins);人类(Humans);成像, 三维(Imaging, Three-Dimensional);免疫组织化学(Immunohistochemistry);原位杂交(In Situ Hybridization);吲哚类(Indoles);注射, 脑室内(Injections, Intraventricular);白细胞介素1(Interleukin-1);溶酶体相关膜蛋白质2(Lysosomal-Associated Membrane Protein 2);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);微丝蛋白质类(Microfilament Proteins);小神经胶质细胞(Microglia);显微镜检查, 共焦(Microscopy, Confocal);肽碎片(Peptide Fragments);吞噬作用(Phagocytosis);斑块, 淀粉样(Plaque, Amyloid);早老素1(Presenilin-1);RNA, 信使(RNA, Messenger);时间因素(Time Factors);Toll样受体2(Toll-Like Receptor 2);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);全身照射(Whole-Body Irradiation)
DOI
10.1016/j.neuron.2006.01.022
PMID
16476660
发布时间
2023-02-07
- 浏览40
Neuron
489-502页
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