TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.
第一作者:
Marc,Ehlers
第一单位:
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA.
作者:
主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);自身抗体(Autoantibodies);B-淋巴细胞(B-Lymphocytes);基因表达调控(Gene Expression Regulation);免疫球蛋白G(Immunoglobulin G);红斑狼疮, 系统性(Lupus Erythematosus, Systemic);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);髓样分化因子88(Myeloid Differentiation Factor 88);受体, IgG(Receptors, IgG);信号传导(Signal Transduction);Toll样受体9(Toll-Like Receptor 9)
DOI
10.1084/jem.20052438
PMID
16492804
发布时间
2018-11-13
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