换一批Development of N-2,4-pyrimidine-N-phenyl-N'-alkyl ureas as orally active inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 2.
第一作者：
Jennifer A,Maier
第一单位：
Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Rd., Mason, OH 45040, USA.
作者：
医学主题词
腺苷三磷酸(Adenosine Triphosphate);动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);关节炎, 实验性(Arthritis, Experimental);结合部位(Binding Sites);结晶学, X线(Crystallography, X-Ray);疾病模型, 动物(Disease Models, Animal);药物评价, 临床前(Drug Evaluation, Preclinical);氢键合(Hydrogen Bonding);碘醋酸盐类(Iodoacetates);脂多糖类(Lipopolysaccharides);模型, 分子(Models, Molecular);分子结构(Molecular Structure);骨关节炎(Osteoarthritis);苯脲化合物(Phenylurea Compounds);嘧啶类(Pyrimidines);大鼠(Rats);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/j.bmcl.2006.03.096
PMID
16632350
发布时间
2013-11-21
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