The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.
第一作者:
Mark,Sabat
第一单位:
Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. sabat.mp@pg.com
作者:
医学主题词
细胞系(Cell Line);化学, 药物(Chemistry, Pharmaceutical);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);人类(Humans);脂多糖类(Lipopolysaccharides);模型, 化学(Models, Chemical);模型, 分子(Models, Molecular);嘌呤类(Purines);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1016/j.bmcl.2006.05.050
PMID
16750367
发布时间
2009-11-19
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