换一批
换一批Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis.
作者：
主题词
3',5'-环AMP磷酸二酯酶类(3',5'-Cyclic-AMP Phosphodiesterases);动物(Animals);体重(Body Weight);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);脑脊髓炎, 自身免疫性, 实验性(Encephalomyelitis, Autoimmune, Experimental);神经胶质原纤维酸性蛋白质(Glial Fibrillary Acidic Protein);脂多糖类(Lipopolysaccharides);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);多发性硬化(Multiple Sclerosis);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);原癌基因蛋白质c-fos(Proto-Oncogene Proteins c-fos);吡啶类(Pyridines);咯利普兰(Rolipram);脊髓(Spinal Cord);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1124/jpet.106.106096
PMID
16809479
发布时间
2013-11-21
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