Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
第一作者:
Gong,Yang
第一单位:
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.
作者:
主题词
动物(Animals);抗原, 多瘤病毒转化(Antigens, Polyomavirus Transforming);印迹法, 蛋白质(Blotting, Western);催化域(Catalytic Domain);细胞分化(Cell Differentiation);细胞系, 转化(Cell Line, Transformed);细胞转化, 肿瘤(Cell Transformation, Neoplastic);上皮细胞(Epithelial Cells);女(雌)性(Female);遗传载体(Genetic Vectors);人类(Humans);免疫酶技术(Immunoenzyme Techniques);核型分析(Karyotyping);角蛋白8(Keratin-8);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);卵巢(Ovary);末端转移酶端粒(Telomerase);端粒(Telomere);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1093/carcin/bgl115
PMID
16829690
发布时间
2022-02-27
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Carcinogenesis
174-82页
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