In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration.
第一作者:
Prateek K,Buch
第一单位:
Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
作者:
主题词
动物(Animals);动物, 基因修饰(Animals, Genetically Modified);细胞系(Cell Line);细胞存活(Cell Survival);睫状神经营养因子(Ciliary Neurotrophic Factor);依赖病毒(Dependovirus);疾病模型, 动物(Disease Models, Animal);基因表达(Gene Expression);胶质细胞源性神经营养因子(Glial Cell Line-Derived Neurotrophic Factor);人类(Humans);中间丝蛋白质类(Intermediate Filament Proteins);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);神经组织蛋白质类(Nerve Tissue Proteins);神经元(Neurons);光感受器细胞(Photoreceptor Cells);大鼠(Rats);视网膜变性(Retinal Degeneration)
DOI
10.1016/j.ymthe.2006.05.019
PMID
16872907
发布时间
2022-01-29
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Molecular therapy
700-9页
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