Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis.
作者:
主题词
青少年(Adolescent);成年人(Adult);发病年龄(Age of Onset);老年人(Aged);老年人, 80以上(Aged, 80 and over);儿童(Child);结肠炎(Colitis);结肠炎, 溃疡性(Colitis, Ulcerative);Crohn病(Crohn Disease);女(雌)性(Female);移码突变(Frameshift Mutation);基因型(Genotype);纯合子(Homozygote);人类(Humans);回肠疾病(Ileal Diseases);肠瘘(Intestinal Fistula);男(雄)性(Male);中年人(Middle Aged);Nod2信号接头蛋白质(Nod2 Signaling Adaptor Protein);复发(Recurrence)
DOI
10.1080/00365520600703900
PMID
17101573
发布时间
2006-11-14
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