换一批
换一批Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
作者：
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);生物利用度(Biological Availability);Caco-2细胞(Caco-2 Cells);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);酶抑制剂(Enzyme Inhibitors);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);羟肟酸类(Hydroxamic Acids);指示剂和试剂(Indicators and Reagents);注射, 静脉内(Injections, Intravenous);小鼠(Mice);微粒体, 肝(Microsomes, Liver);大鼠(Rats);构效关系(Structure-Activity Relationship);噻吩类(Thiophenes)
DOI
10.1016/j.bmcl.2006.10.045
PMID
17107790
发布时间
2020-05-11
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