Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.
第一作者:
A,Gaussmann
第一单位:
Institute of Pharmaceutical Biology/ZAFES, JWG-University Frankfurt, Biocenter, Frankfurt/Main, Germany.
作者:
医学主题词
动物(Animals);细胞凋亡(Apoptosis);细胞周期(Cell Cycle);细胞, 培养的(Cells, Cultured);染色体, 人, 4对(Chromosomes, Human, Pair 4);周期素依赖激酶抑制蛋白质类(Cyclin-Dependent Kinase Inhibitor Proteins);基因表达谱(Gene Expression Profiling);人类(Humans);小鼠(Mice);突变(Mutation);髓淋巴细胞性白血病蛋白质(Myeloid-Lymphoid Leukemia Protein);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);聚合酶链反应(Polymerase Chain Reaction);转录因子(Transcription Factors)
DOI
10.1038/sj.onc.1210125
PMID
17130830
发布时间
2007-05-17
- 浏览13
Oncogene
3352-63页
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