Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.
第一作者:
Bertrand,Le Bourdonnec
第一单位:
Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341, USA. blebourdonnec@adolor.com
作者:
主题词
动物(Animals);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);结晶学, X线(Crystallography, X-Ray);鸟苷5'-O-(3-硫代三磷酸)(Guanosine 5'-O-(3-Thiotriphosphate));人类(Humans);配体(Ligands);模型, 分子(Models, Molecular);分子构象(Molecular Conformation);哌啶类(Piperidines);放射配体测定(Radioligand Assay);受体, 阿片样, μ(Receptors, Opioid, mu);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship)
DOI
10.1021/jm060486f
PMID
17149858
发布时间
2006-12-07
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