Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
第一作者:
Sovan,Sarkar
第一单位:
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, United Kingdom.
作者:
医学主题词
动物(Animals);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);自噬(Autophagy);COS细胞(COS Cells);人类(Humans);杭廷顿病(Huntington Disease);小鼠(Mice);分子伴侣(Molecular Chaperones);突变(Mutation);神经组织蛋白质类(Nerve Tissue Proteins);核蛋白质类(Nuclear Proteins);帕金森病(Parkinson Disease);蛋白激酶类(Protein Kinases);西罗莫司(Sirolimus);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);海藻糖(Trehalose);α突触核蛋白(alpha-Synuclein)
DOI
10.1074/jbc.M609532200
PMID
17182613
发布时间
2025-05-29
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