换一批
换一批L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.
作者：
主题词
3',5'-环AMP磷酸二酯酶类(3',5'-Cyclic-AMP Phosphodiesterases);氨基吡啶类(Aminopyridines);动物(Animals);脱辅酶类(Apoenzymes);猪蛔虫(Ascaris suum);哮喘(Asthma);苯甲酰胺类(Benzamides);支气管收缩(Bronchoconstriction);羧酸类(Carboxylic Acids);认知障碍(Cognition Disorders);环AMP(Cyclic AMP);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);环己酸类(Cyclohexanecarboxylic Acids);环丙烷类(Cyclopropanes);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);豚鼠(Guinea Pigs);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);注射, 腹腔内(Injections, Intraperitoneal);干扰素γ(Interferon-gamma);男(雄)性(Male);分子结构(Molecular Structure);腈类(Nitriles);卵白蛋白(Ovalbumin);聚合酶链反应(Polymerase Chain Reaction);喹啉类(Quinolines);大鼠(Rats);敏感性与特异性(Sensitivity and Specificity);绵羊(Sheep)
DOI
10.1016/j.bcp.2007.03.010
PMID
17428447
发布时间
2014-11-20
- 浏览11
Biochemical pharmacology
1971-81页
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